Cutting-edge analysis reveals how different drugs interact with the same target

(Osaka University) Osaka University-led researchers identified differences in how three drugs bind to tumor necrosis factor, a key mediator of inflammatory disease. The team used sedimentation velocity analytical ultracentrifugation to investigate drug-target binding in a physiological environment and at clinically-relevant concentrations. They revealed differences between the three drugs in the size and structure of the complexes formed, which may explain differences in the drugs' clinical effi...